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Various works published by faculty, physicians and students

Research Publications

SCNM faculty, physicians and students have published various works on numerous topics in notable medical and scholarly journals. Upcoming, recent, and past research publications can be found below.

Accessing Research Articles: Students can always request Full Text Journal articles, free of charge for SCNM students and alumni, from the SCNM Library: library@scnm.edu

Turner, T., Ruiz, G., Gerstel, J., and Langland, J.O. β-lactam antibiotic and potentiation constituents from the botanical, Larrea tridentata. PlosONE (submitted).

Zyglis, E. and Langland, J.O. Anti-bacterial activity of heat sterilized honey based on floral origin. J. Medicinal Food (submitted).

Hartwell, L., Stein, A., Gillen, A., Jones, G., Nelson, E., and Langland, J.O. Evaluation of the antibacterial activity of botanicals used during the Black Plague.  Scientific Reports (submitted).

Abers, M., Schroeder, S., Puchalski, K., and Langland, J.O. Antimicrobial activity of the aromatic constituents from essential oils. Scientific Reports (submitted).

Williams, A., Scally, G., and Langland, J. O. A Topical Botanical Therapy for the Treatment of Canine Papilloma Virus Associated Oral Warts:  A Case Report.Adv. Integrative Med. (submitted).

Kannan, L., Kumar, A., Kumar, A., Jacobs, B., and Langland, J.O. Anti-herpes virus activity of the carnivorous botanical, Sarracenia purpurea. Scientific Reports (submitted).

Ferreira, V., and Langland, J.O. Treatment of Herpes Zoster with Botanical Interventions: Case Report. Integrative Med. Res. (submitted).

Koehler, H., Puchalski, K., Ruiz, G., Jacobs, B., and Langland, J.O. The Role of Endophytic/Epiphytic Bacterial Constituents in the Immunostimulatory Activity of the Botanical, Astragalus membranaceus. Yale J. Biol Med (accepted, publishing September).

Nelson, E., Ruiz, G., Kozin, A., Turner, T., Langland, E., and Langland, J.O. Resolution of Recurrent Oro-facial Herpes Simplex Using a Topical Botanical Gel: A Case Report. Yale J. Biol Med (accepted, publishing September).

M Asariha, A Chahardoli, N Karimi, M Gholamhosseinpour, A Khoshroo, …  Green synthesis and structural characterization of gold nanoparticles from Achillea wilhelmsii leaf infusion and in vitro evaluation. Bulletin of Materials Science 43 (1), 57 2020.

MR Golpayegani, Y Shokoohinia, S Khashman, N Jamshidi, R Tahvilian, … The Effect of oral Administration of Cichorium Intybus on Reduction of Liver Enzymes in Patients with Major Thalassemia: Randomized Clinical Trial Study (RCTs). International Journal of Pediatrics. 2020.

M Mavaei, A Chahardoli, Y Shokoohinia, A Khoshroo, A Fattahi. One-step synthesized silver nanoparticles using isoimperatorin: evaluation of photocatalytic, and electrochemical activities. Scientific reports 10 (1), 1-122. 2020.

F Jalilian, A Chahardoli, K Sadrjavadi, A Fattahi, Y Shokoohinia. Green synthesized silver nanoparticle from Allium ampeloprasum aqueous extract: Characterization, antioxidant activities, antibacterial and cytotoxicity effects. Advanced Powder Technology. 2020.

MB Majnooni, S Fakhri, Y Shokoohinia, M Mojarrab, S Kazemi-Afrakoti, … Isofraxidin: Synthesis, Biosynthesis, Isolation, Pharmacokinetic and Pharmacological Properties. Molecules 25 (9), 2040. 2020.

A Chahardoli, F Jalilian, Z Memariani, MH Farzaei, Y Shokoohinia. Analysis of organic acids. Recent Advances in Natural Products Analysis, 767-823. 2020.

B Shahbazi, S Feyzmand, F Jafari, N Ghiasvand, G Bahrami, A Fattahi, … Antidiabetic Potential of Prosopis farcta Roots: In Vitro Pancreatic Beta Cell Protection, Enhancement of Glucose Consumption, and Bioassay-Guided Fractionation. Evidence-Based Complementary and Alternative Medicine. 2020.

M Amiri, J Navabi, Y Shokoohinia, F Heydarpour, G Bahrami, L Behbood, … Efficacy and safety of a standardized extract from Achillea wilhelmsii C. Koch in patients with ulcerative colitis: A randomized double blind placebo-controlled clinical trial. Complementary therapies in medicine 45, 262-268. 2019.

KR Dehmoradkhani, A Jafari, Y Shokoohinia, SA Emami, M Mojarrab. Flavonoids from the Aerial Parts of Artemisia biennis Willd. Pharmaceutical Sciences 25 (4), 364-368. 2019.

P Derakhshande, SJ Navabi, Y Shokoohinia, H Rouhi-Broujeni, F Deris, … Efficacy and safety of Achillea wilhelmsii C. Koch capsules on symptom severity and quality of life in patients with irritable bowel syndrome: a randomized, placebo-controlled Journal of Complementary and Integrative Medicine 16 (4). 2019.

L Hosseinzadeh, Y Shokoohinia, M Arab, E Allahyari, M Mojarrab. Cytotoxic and Apoptogenic Sesquiterpenoids from the Petroleum Ether Extract of Artemisia aucheri Aerial Parts. Iranian Journal of Pharmaceutical Research: IJPR 18 (1), 391. 2019.

Kadar GE, Thompson HG. Obesity bias among preclinical and clinical chiropractic students and faculty at an integrative health care institution: A cross-sectional study.
Journal of Chiropractic Education. 33:1, 8-15. 2019.

Kannan, L., Kumar, A.V., Kumar, A., Jacobs, B.L. and Langland. J.O. Anti-herpes virus activity of the carnivorous botanical, Sarracenia purpurea.  Yale J. of Biology and Medicine (submitted). 2019.

Koehler, Heather; Puchalski, Keely; Guillermo, Ruiz; Bertram Jacobs; Langland, Jeffrey. The Role of Endophytic Bacteria Constituents in the Immunostimulatory Activity of the Botanical, Astragalus membranaceus. Yale J. of Biology and Medicine (submitted). 2019.

Nelson, E.O.; Ruiz, G.G., Kozin, A.F.,Turner, T.C., Langland, E.V. and Langland, J.O. (2019). Resolution of Recurrent Oro-facial Herpes Simplex Using a Topical Botanical Gel: A Case Report.  Yale J. of Biology and Medicine (submitted).

H Rahmani, A Fattahi, K Sadrjavadi, S Khaledian, Y Shokoohinia. Preparation and Characterization of Silk Fibroin Nanoparticles as a Potential Drug Delivery System for 5-Fluorouracil. Advanced Pharmaceutical Bulletin 9 (4), 601. 2019.

S Taheri, M Nazifi, M Mansourian, L Hosseinzadeh, Y Shokoohinia. Ugi efficient synthesis, biological evaluation and molecular docking of coumarin-quinoline hybrids as apoptotic agents through mitochondria-related pathways. Bioorganic chemistry 91, 103147. 2019.

Turner, Tiffany; Guillermo, Ruiz; Gerstel, Johanne; Langland, Jeffrey (2019). β-lactam antibiotic and potentiation constituents from the botanicals Larrea tridentata and Arctostaphylos uva-ursi. Yale J. of Biology and Medicine (submitted).

Williams, A., Scally, G., Langland, J. O. A Topical Botanical Therapy for the Treatment of Canine Papilloma Virus Associated Oral Warts: A Case Report.  Yale J. of Biology and Medicine (submitted)2019.

Q Zhou, Y Liu, Y Tang, Y Shokoohinia, AG Chittiboyina, M Wang, … Identification of Potential Skin Sensitizers in Myrrh. Cosmetics 6 (3), 47. 2019.

Zyglis, Elliot; Langland, Jeffrey. Anti-bacterial activity of heat-sterilized honey based on floral origin. (manuscript in preparation). 2019.

Cahill, T., Ruiz, G., Turner, T., Wagner, C., Jacobs, B., and Langland, J. Antiviral  activity of metal chelates of caffeic acid and similar compounds towards herpes simplex and ebola viruses. Antiviral Research 160:143-150. 2018.

Falkner, M., Deng, Y., Langland, J.O. Acupuncture for the Treatment of Lisinopril Associated Diarrhea: A Case Report.  J. Chin. Med. 116:59-61. 2018.

Hoang, M., Deng, Y., Hilmi, Y., Langland, J.O. Treatment of Anxiety and Insomnia with Acupuncture and Chinese Herbs. A Case Report. J. Chinese Medicine 118:32-35. 2018.

Kadar GE, Thompson HG. Obesity bias among preclinical and clinical chiropractic students and faculty at an integrative health care institution: A cross-sectional study. Journal of Chiropractic Education. 2018 Jul 25. [Epub ahead of print]

Langland, J.O., Riaz, S., Van Dyke, A., and Beck, F.D. Treatment of Pain Associated with Lyme Disease Neuralgia Using Perineural Injection Therapy: A Case Report. Current Research in Complementary and Alternative Medicine CRCAM-119. DOI:10.29011/2577-2201/100019. 2018.

Mitchell, W., Ruiz, G., Turner, T., Langland, J. Heat stress as a tool for detoxification.  J. Evol and Health, Vol 2, Iss 3, Art 14. 2018.

Muro, E., Ruiz, G., Wise, J., Turner, T., and Langland, J. Basin Glove: Disposable Wash Basin Liner in the Prevention of Hospital-Acquired Infections. Infectious Control Tips, June 11, 2018.

Salisbury, L., Deng, Y., Hilmi, Y., Langland, J.O. The Treatment of Meniere’s Disease with Acupuncture and Chinese Medicine. A Case Study. J. Chinese Medicine 117:68-71. 2018.

Seenauth, C., Inouye, V., & Langland, J. O. Dextrose Prolotherapy for Chronic Shoulder Pain: A Case Report. Alternative Therapies In Health And Medicine, 24(1), 56-60. 2018.

Turner, T., Ruiz, G., Mitchell, W., Langland, J. Schizophrenia: An evolutionary explanation for a maladapted modern environment. J. Evol and Health, Vol 2, Iss 3, Art 2. 2018.

Turner, T., Alonso, J., Wise, J., Naser, G., Jeffries, B., Arnold, K., Morin, T., Chen, M., Fiorillo, M., Finazza, T., Sukhorukov, E., Ford, M., Clark, D., Stein, A., Drought, K. Steen, T., Wright, B., Irwin, R., Ruiz, G., Kozin, A., Nelson, E., and Langland, J.O. Identification of botanicals with potential therapeutic use against methicillin-resistant Staphylococcus aureus (MRSA) infections. Phytotherapy Res. 2018 Sep 25 doi: 10.1002/ptr.6198

Cooper, J., Deng, Y., and Langland, J.Enhancing Recovery from Bell’s Palsy with Acupuncture and Botanical Therapy: A Case Report.   J. Chin. Med. JCM 114/56. 2017.

Huynh, T. P., Jancovich, J. K., Tripuraneni, L., Heck, M. C., Langland, J. O., & Jacobs, B. L. Characterization of a PKR inhibitor from the pathogenic ranavirus, Ambystoma tigrinum virus, using a heterologous vaccinia virus system.  Virology, 511290-299. doi.012:10.1016/j.virol.2017.08. 2017.

Huynh, T., Jancovich, J., Tripuraneni, L., Heck, M., Langland, J. and Jacobs, B. Characterization of a PKR inhibitor from the pathogenic ranavirus, Ambystoma tigrinum virus, using a heterologous vaccinia virus system.  Virology.  511:290-299. 2017.

Kadar GE, Thompson HG. The affective domain in healthcare education. Journal of Nutritional Health & Food Engineering. Assumed or Assessed? 6(4):00207. 2017.

Koehler, H., Cotsmire, S., Langland, J., Karen V Kibler, K., Daniel Kalman, D., Upton, J., Mocarski, E., Jacobs, B. Inhibition of DAI-dependent necroptosis by the Z-DNA-binding domain of the vaccinia virus innate immune evasion protein, E3. PNAS. 10.1073/pnas.1700999114. 2017.

Kwiatkowski, K., Rice, E., Langland, J.O. Integrative Treatment of Chronic Abdominal Bloating and Pain Associated with Small Intestinal Bacterial Overgrowth. A Case Report. Alt Ther Health Med. 23:56-61. 2017.

Kwiatkowski, L., Rice, E., & Langland, J. Integrative Treatment of Chronic Abdominal Bloating and Pain Associated With Overgrowth of Small Intestinal Bacteria. A Case Report. Alternative Therapies In Health And Medicine, 23(4), 56-61. 2017.

Mauss, J., Retz, M., Dilts, R., Langland, J.O. Multiple Sampling and SAF-Fixative Triple-Faeces-Testing for Dysbiosis and Pathogenic Infections of the Gastrointestinal Tract: Case Report. Alt Ther Health Med. Oct 21. Pii: AT5587. 2017.

Nelson, E., Lasku, A. and Langland, J.O. Treatment of an Athlete’s Plantar Warts using a Synergistic Botanical Blend: A case report. Alt Ther Health Med 23:51-54. 2017.

Otto, M., Magerus, T., and Langland J.O. The use of intravenous glutathione for symptom management of Parkinson’s Disease. A case report. Alt Ther Health Med Nov 4. Pii AT494, ISSN#1078-6791. 2017.

Ruiz, G., Turner, T., Nelson, E., Sparks, L., and Langland, J. Development of resistance to antimicrobial botanicals. Journal of Evolution and Health. Vol. 2: Iss. 2, Article 3. https://doi.org/10.15310/2334-3591.1065. 2017.

Allen, J., Deng, Y., and Langland, J.O.  Treatment of chronic migraine pain with acupuncture and herbal medications: case report. J. Chinese Medicine 110:18-22. 2016.

Denzler, K., Huynh T., Jacobs, B., and Langland, J. Melissa officinalis extract inhibits herpes simplex virus I glycoprotein B interaction with herparin sulfate. Herbal Medicine. Open Access Vol 2, No 2:12. 2016.

Denzler, K., Moore, J., Harrington, H., Waters, R., White, S., Morrill, K., and Langland, J. Characterization of the physiological response following in vivo administration Astragalus membranaceus. Evid. Based Comp. Alt. Med. Vol 2016, Art 6861078. 2016.

Ferreira, V., Ruiz, G., Jacobs, B.L., Denzler, K., Waters, R., Chamberlain, R., Proefrock, K.J., and Langland, J.O. Treatment of Verruca Vulgaris (common warts) with a synergistic botanical blend: case report. Nat. Doc. News and Review (May, 2016).

Ferreira, V., Dickerson. W., Farr, D., Barraza, M., Banker, R., Dutton, J., Cervigni, M., Willhauck, M., Tifre, L., Mayman, S., Stone, S., Bushman, S., Hull, G., Morgan, R., Hoover, T., Mittman, A., Sparks, L., Smithers, J., Miles, D., Calvert, D., and Langland, J.O.  Characterization of the effect of botanical tinctures and oils on the growth and differentiation of Candida albicans. Herbal Medicine Open Access Vol 2, No 2:14. 2016.

Grise, D., Peyman, T., Langland, J.O. Remission of schizoaffective disorder utilizing integrative medicine: a case report. Alt Ther Health Med (accepted for publication).2016

Kwiatkowski, L., Mitchell, J., and Langland, J.O. Resolution of allergic rhinitis and reactive bronchospasm with natural interventions and food specific IgG elimination. A case report. Alt Ther Health Med (accepted for publication). 2016.

Nelson E, Kozin A, Ruiz G, Turner T, and Langland JO. Quality Control of Botanical Tinctures: Endogenous Bacterial Flora Present in Botanical Extractions. HSOA J Altern Complement Integr Med 2: 012. doi:http://dx.doi.org/10.24966/ACIM-7562/100012. 2016.

Ruiz, G. G., Nelson, E. O., Kozin, A. F., Turner, T. C., Waters, R. F., & Langland, J. O. A Lack of Bioactive Predictability for Marker Compounds Commonly Used for Herbal Medicine Standardization. Plos One, 11(7), e0159857. doi:10.1371/journal.pone.0159857. 2016.

Ruiz, G., Nelson, E., Kozin, A., Turner, T., Waters, R., and Langland, J.O. A lack of bioactive predictability for marker compounds commonly used for herbal medicine preparationPlos One (in press). 2016.

Ferreira, V., Jacobs, B.L., Denzler, K., Waters, R., Chamberlain, R., Proefrock, K.J., and Langland, J.O. Treatment of Herpes Zoster with botanical interventions. A case report. Nat. Doc. News and Review. November, 2015.

Grise, D.E., McAllister, H.M., Langland, J.O. Improved clinical outcomes of patients with type 2 diabetes mellitus utilizing integrative medicine: a case report.
Global Adv. Health Med. 2015. 4:57-61.

Virdee, K., Uwase, J., Baral, M., Cronin, C., Langland, J.O. Food specific IgG antibody-guided exclusion diets followed by resolution of asthma symptoms and reduction in pharmacological interventions in two patients: a case report. Global Adv. Health Med. 4: 62-66. 2015.

Wheeler, M., Oskin, J.and Langland, J.O. Alternating symptoms in the homeopathic treatment of bipolar disorder: platinum metallicum. A case report. Amer. J. Homeo. Med. 2015. 108:145-153.

Wolf, J., Sparks, L., Deng, Y., Langland, J.O. Restoration of function following traumatic brain injury with acupuncture. A case report. Global Adv. Health Med. 2015. 4:52-57.

Snowden, R., Harrington, H., Morrill, K., LaDeana, J., Orian, M. Lopez, E., Rezaie, S., Hassberger, K., Familoni, D., Moore, J., Virdee, K., Albornoz-Sanchez, L., Walker, M., Cavins, J., Russell, T., Guse, E., Reker, M., Tschudy, Onyria, Wolf, J., True, T., Ukaegbu, O., Ahaghotu, E., Jones, A., Polanco, S., Rochon, Y., Waters, R., Langland, J.  A comparison of the anti-Staphylococcus aureus activity of extracts from commonly used medicinal plants. Journal of Alternative and Complementary Medicine. 2014 May 7. 20 (5): 375-382.

Swanson, M., Langland, J.O. “Voices of Naturopathic Research”. Nat Doc News and Review. August 2014.

Arndt, W., Mitnik, C., Denzler, K.L., Waters, R.F., Jacobs, B.L., Rochon, Y., and Langland, J.O.  Rediscovery of a 19th century cure for smallpox. PLOS ONE 7(3):e32610. Epub 2012 Mar 9

Morrill, K., May, K., Leek, D., Langland, N., Jeane, L., Ventura, J., Skubisz, C., Scherer, S., Lopez, E., Crocker, E., Peters, R., Oertle, J., Nguyen, K., Just, S., Phair, M., Humphrey, M., Payne, D., Jacobs, B., Waters, R, Langland, J.  Spectrum of Anti-microbial Activity Associated with Colloidal Silver. J. Alt. Medicine. (2012 Sep 27). 19 : 224-231.

Denzler, K.L., Waters, R.F., Jacobs, B.L., Rochon, Y., and Langland, J.O. (2010). Regulation of inflammatory gene expression by immunostimulatory botanicals. PLoS ONE. 2010. 5 :e12561.